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KMID : 0363220110490020155
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Korean Journal of Dermatology
2011 Volume.49 No. 2 p.155 ~ p.158
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Imatinib Mesylate (Gleevec(TM))-induced Lichenoid Drug Eruption Improved by Tentative Dose-reduction and Topical Steroid
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Yang Jung-Hoon
Shin Jung-Woong
Kim Hyung-Dong
Park Young-Lip
Lee Sung-Yul
Whang Kyu-Uang
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Abstract
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Imatinib mesylate (GleevecTM) is an oral anticancer drug. It works as a selective and competitive inhibitor of tyrosine kinases such as bcr-abl protein, c-kit, and platelet-derived growth factor receptors (PDGFR). GleevecTM is a first-line therapeutic agent for chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors, but causes various adverse cutaneous reactions. We herein report on a case of lichenoid drug eruption induced by GleevecTM in a patient with a malignant gastrointestinal stromal tumor.
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KEYWORD
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GleevecTM, Imatinib mesylate, Lichenoid drug eruption
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